AOD 9604
AOD9604 is a peptide fragment (Fragment 177-191) of the C-terminus of Human Growth Hormone to which a tyrosine is added at the N-terminal end. AOD stands for “Anti-Obesity Drug”. This peptide has an amino acid sequence that mimics the lip lytic region of human growth hormone (the region of this hormone thought to be responsible for burning fat) and it has been promoted variously as a weight loss supplement, as an aid to muscle and cartilage repair, and a treatment for osteoarthritis by its manufacturers. Studies have suggested that AOD9604 is more effective than its predecessor AOD9401. Recent clinical research studies have shown that AOD9604 did show a reduction of body fat in the mid abdominal area in both obese, over-weight, and average built people.
AOD 9604 Lab Results
In laboratory tests on fat cells, the fragment released fat specifically from obese fat cells but not from lean ones. It also reduced new fat accumulation in all fat cells and enhanced the burning of fat. Recent research has shown AOD 9604 to be an extremely potent and effective fat burner. Metabolic is developing AOD-9604 for the potential treatment of obesity.
Research studies have shown that AOD9604 actually acts on the reduction of excessive adipose tissues such as those in the abdominal area, increase in muscle mass, and enhances the lipid content of the body. AOD 9604 has resulted in a short-period increase in blood glucose and a more sustained increase in plasma insulin, together with other fragments such as 172-191, 177-191 and 178-191. The functionality of the peptide depends on the informational sequence. It should also have the correct physical configuration (Ng and Borstein 1978). Furthermore, a region of high accessibility to proteases and also rich in proline, have been demonstrated to affect the conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as the hinge for the pivoting of the two subdomains.
Technical Information:
CAS.NO.: 221231-10-3;
Unit Size: 5mg/vial;
Synonyms: Fragment 177-191;
Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe;
Purity: ≥99% (HPLC)
Physical State: Lyophilized Powder;
Solubility: Soluble in water or 1% acetic acid;
Storage Instructions: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C;
