Description
Enclomiphene Citrate Research Chemical Liquid 25mg x 30ml
SYNONYMS: Enclomiphene, Enclomid, Enclomifene Research Chemical, cis-Clomifene, Cisclomiphene, (E)-Clomifene, RMI-16289, Enclomiphene Citrate Research Chemical
Enclomiphene Research Chemical is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. Enclomiphene constitutes the trans-stereoisomer of clomiphene citrate. Clomiphene citrate, also known as Clomid, ia a drug widely prescribed for several decades treating female ovulatory dysfunction. Because of the antagonistic effects of enclomiphene, enclomiphene citrate has the potential to increase serum testosterone levels in men with secondary hypogonadism. It does this by restoring physiological endogenous testosterone secretion while maintaining testicular volume and, potentially, spermatogenesis. In clinical trials conducted to date, enclomiphene demonstrated significant efficacy in the physiological restoration of testosterone levels in males with secondary hypogonadism.
Chemical Structure
Chemical Description
To activate them, Enclomiphene Citrate Research Chemical binds to estrogen receptors. In addition, it acts as an agonist or an antagonist based on the exact tissue type and the hormonal milieu. It is classified as first generation because of the ability to showcase estrogen agonist properties. On the other hand, Enclomiphene Citrate is also classified as second generation due to the patterns of tissue specificity.
Pharmacology
Enclomiphene Citrate is a triphenyl ethylene stilbene derivative. It acts as an estrogen antagonist or as an estrogen agonist based on the target tissue that it applies on. Furthermore, enclomiphene and zuclomiphene are clomiphene isomers.
The chemical is orally bioavailable in the form of Enclomiphene citrate salt. Moreover, it is available in the form of antiestrogenic and tissue selective estrogenic activities. Since this is a selective estrogen receptor modulator, it has got the ability to block the negative feedback given by the endogenous estrogens. Hence, the release of gonadotropin releasing hormone will be stimulated from hypothalamus.
It has also been identified that Enclomiphene Citrate binds to the estrogen receptors that can be found in the breast cancer cells. As a result, the inhabitation of estrogen hormone stimulated proliferation is taken place within the cell populations.
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