IGF-2 (Insulin-like Growth Factor-2)
Insulin-like growth factor II goes by many names such as IGF-2, Somatomedin-A, IGF-II, and IGF2.
Like relaxin and insulin, IGFs such as IGF-2 or IGF-II belong to the insulin family. They represent a group of structurally related polypeptide with varying degree of biological functions. The IGFs are a vital part of pre-adolescent mammalian growth.
Chemical Structure of IGF-2 Peptide
Aliases: IGF2, C11orf43, GRDF, IGF-II, PP9974, insulin like growth factor 2
IGF-2, just like most polypeptide growth factors in the insulin family, plays a crucial role in growth as well as development.
IGF2 are potent mitogens for cultured cells. IGF 2’s expression occurs in placenta lactogen during prenatal development. IGF-II’s importance is in fetal development. IGF-II’s variations associate directly to our BMI (Body Mass Index). Of all the characterized growth factors, IGF2 is the most intricately regulated. IGF-Binding proteins as well as differential expression of receptors control the activities of IGF2.
The IGF2 gene’s located on Chromosome 11P15.5 which is a region containing several imprinted genes. In humans, IGF2 is imprinted and consequently it’s expression favors the paternally inherited allele. However, in certain brain regions, a loss of imprinting occurs from both parental alleles.
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Read more about IGF2 at this wiki page.