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LL-37 5mg (CAP-18)

LL-37 is a renowned research chemical, specifically synthesized as a synthetic peptide for advanced laboratory use. Known for its potent antimicrobial properties, LL-37 plays a pivotal role in studying the human immune response. This peptide is invaluable for researchers focusing on peptide interactions, receptor analysis, and binding affinity experiments.

Our LL-37 solution for laboratory use is meticulously crafted to meet the highest standards of quality and purity. Each batch undergoes rigorous testing to ensure reliable and consistent results in your research projects.

Note: LL-37 is strictly for research use only. It is not intended for human consumption or any therapeutic applications. Researchers can confidently buy LL-37 for research purposes from our trusted supply.

$64.99

LL-37 Solution: USA LL-37 Vendor & Researcher Guide

Are you interested in exploring the LL-37 peptide and its potential as an antimicrobial agent? 

LL-37 is a fascinating antimicrobial peptide widely studied for its powerful defensive capabilities. It’s crucial to understand that LL-37 is exclusively intended for research purposes and is not for human consumption.

For researchers and scientists, finding a reliable source of high-quality LL-37 is essential. Our website is your trusted partner, offering the best peptide for sale online with an unwavering commitment to quality and integrity.

When you buy online from us, you’re assured of sourcing from a top-tier peptide supplier USA, known for providing superior peptide products. Dive into the world of LL-37, and discover why it’s a sought-after peptide solution in the research community.

What is LL-37?

LL-37 is a unique peptide known for its antimicrobial properties and plays a critical role in the body’s host defense mechanisms. Structurally, LL-37 is composed of 37 amino acids, giving it a robust peptide structure with a molecular weight of approximately 4.5 kDa.

This peptide is derived from a larger protein, cathelicidin, and its synthesis involves the enzymatic cleavage of this precursor to produce the active LL-37 form. Chemically, LL-37 is characterized by a rich composition that allows it to interact effectively with microbial membranes.

As a host defense peptide, LL-37 exhibits a broad spectrum of activity against bacteria, fungi, and viruses. This antimicrobial action is attributed to its ability to disrupt microbial cell membranes, a feature central to its function.

Historically, LL-37 was first identified as a significant component of the innate immune system, with current research delving into its multifaceted roles beyond antimicrobial defense. Studies have highlighted LL-37’s involvement in TB-500 immune modulation, making it a peptide of significant interest in various research fields.

How LL-37 Works

The mechanism of action of LL-37 is multifaceted, primarily involving interactions with microbial membranes. LL-37 binds to the membranes of bacteria and other pathogens, disrupting their structure and leading to cell lysis.

This receptor binding capacity is crucial for its effectiveness as an antimicrobial agent. Beyond its direct antimicrobial effects, LL-37 is known for modulating immune responses. It influences various immune cells, enhancing their activity and contributing to a robust immune defense.

In laboratory settings, LL-37 has been observed to exhibit potent bioactivity, affecting various biological processes. Its ability to bind and interact with different cellular receptors underscores its diverse functional roles.

For instance, in peptide interactions, LL-37 has shown the capability to neutralize endotoxins, reducing inflammation and promoting healing. Researchers have also noted its role in signaling pathways that regulate immune responses, making it a valuable peptide in immune modulation studies.

Uses in Scientific Research & Advancement

LL-37’s diverse research applications make it a critical tool in scientific exploration. Its robust antimicrobial peptide functions have been extensively studied for potential therapeutic uses. Researchers utilize LL-37 to explore experimental use in treating infections, wound healing, and inflammatory diseases.

The peptide analysis of LL-37 involves examining its binding affinity to various cellular receptors, providing insights into its role in modulating immune responses and pathogen defense mechanisms.

Significant scientific studies have highlighted LL-37’s potential in clinical research. For instance, its therapeutic potential is being investigated in conditions like cystic fibrosis, where its ability to enhance host defenses could be transformative. The peptide’s capacity to modulate inflammatory responses has also spurred research into its application in chronic inflammatory diseases.

For example, similar to GHRP-6 and IGF-1 LR3, which are also used extensively in experimental research for their roles in growth hormone release and muscle regeneration, LL-37 continues to be a focal point in studies aimed at understanding its broader therapeutic implications. Researchers draw parallels between LL-37 and these peptides due to their shared ability to influence cellular processes and immune functions.

The impact of LL-37 on scientific advancement cannot be overstated. It serves as a model for developing new antimicrobial agents and therapeutic strategies. LL-37 peptide regulation studies provide crucial data that guide the design of next-generation peptides with enhanced efficacy and safety profiles. Overall, LL-37 remains a cornerstone in the field of antimicrobial peptide research, driving forward innovations and potential treatments.

Pharmaceutically Available?

Despite its promising pharmaceutical potential, LL-37 is not currently approved for pharmaceutical use. The peptide’s regulatory status is strictly limited to research applications, and it has not yet overcome the hurdles required for pharmaceutical approval. The journey from laboratory research to clinical application involves rigorous testing and regulatory scrutiny, which LL-37 is still undergoing.

Comparatively, LL-37’s therapeutic potential is similar to other antimicrobial peptides in the research domain, which are also under evaluation for clinical use. The regulatory landscape for peptide products is complex, requiring comprehensive data on safety, efficacy, and manufacturing standards. As researchers continue to explore LL-37’s capabilities, the hope is that future advancements will address these regulatory challenges and open the door to pharmaceutical applications.

In the USA, LL-37 is legal to purchase strictly for research purposes. Its legal status as a research chemical means that it cannot be used for any human or therapeutic applications. When buying LL-37, researchers must adhere to usage restrictions and ensure that their use complies with regulatory guidelines.

Regional restrictions may vary, so it’s important to check local regulations when purchasing LL-37. As a peptide supplier in the USA, we emphasize the importance of compliance with legal considerations. To legally buy LL-37, one must source it from a reputable supplier like us, who ensures adherence to all peptide research chemicals regulations and provides necessary documentation for lawful use.

Not for Human Consumption

It is crucial to reiterate that LL-37 is designated for research purposes only and is not for human consumption. This legal disclaimer serves to inform all potential users of the usage limitations associated with this peptide. The LL-37 peptide is intended solely for laboratory use and experimental settings. Any application outside these parameters is strictly prohibited. This research-only disclaimer underscores our commitment to safety and regulatory compliance in the use of our products.

Indemnification

By purchasing LL-37, buyers acknowledge and accept full responsibility for its safe handling and use in research settings. This legal indemnity clause outlines that the user must adhere to all safety protocols and usage guidelines provided. Responsibilities of the user include following established peptide safety protocols and ensuring that LL-37 is used strictly for research purposes.

Our indemnity terms clarify that any misuse or unintended application of LL-37 is outside our liability scope. We provide a research-only disclaimer to protect both the supplier and the buyer, emphasizing the importance of compliance with all legal and safety considerations during peptide interactions.

Laboratory Usage Guidelines and Safe Handling

To ensure safe and effective use of LL-37 in a laboratory environment, strict laboratory usage guidelines must be followed. This includes proper administration and handling procedures. Researchers should use appropriate protective measures, such as gloves and lab coats, to minimize exposure risks during peptide handling.

For the reconstitution of LL-37, it’s often necessary to use Bacteriostatic Water or Acetic Acid AA to ensure the peptide is properly dissolved and stable for research applications. These solvents are critical for maintaining the integrity of the peptide solution and preventing contamination during use. Safe disposal of any waste material should follow local regulations to maintain laboratory safety. Following these guidelines helps to protect researchers and ensure the integrity of the experiments involving LL-37.

Storage and Precautions

Maintaining LL-37’s stability and effectiveness depends on proper storage conditions. It is recommended to store LL-37 at temperatures below -20°C to preserve its peptide stability. The shelf life of LL-37 can be significantly extended when stored in a lyophilized form and protected from light and moisture.

Adhering to safety protocols during storage is critical. Ensure that LL-37 is kept in clearly labeled, sealed containers to prevent contamination and accidental misuse. When handling the peptide, wearing protective equipment such as gloves and goggles is essential. Following these storage recommendations and precautions helps to maintain the peptide’s quality and ensures safe usage in research applications.

Analyte Information

ParameterDetails
Peptide NameLL-37
Chemical FormulaC₁₈₅H₃₁₅N₅₅O₄₆
Molecular Weight4493.1 Da
SequenceLLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
StructureAlpha-helical structure; linear cationic peptide
SourceDerived from the C-terminal region of the human cathelicidin antimicrobial peptide, hCAP18
PurityTypically ≥ 98% as determined by HPLC
SolubilitySoluble in water, buffers, and various organic solvents
Storage ConditionsStore at -20°C in lyophilized form; once reconstituted, store at 4°C and use within a few weeks
FunctionalityHost defense peptide with antimicrobial, immunomodulatory, and wound-healing properties
Research ApplicationsStudied for its role in immune response, antimicrobial activity, and potential therapeutic uses

Safety Information

Safety ParameterGuidelines and Information
UsageFor research purposes only; not for human or veterinary use
Handling PrecautionsUse personal protective equipment (PPE) including gloves, lab coat, and safety goggles
Inhalation RiskAvoid breathing dust or aerosols; use in a well-ventilated area or fume hood
Skin ContactMinimize direct skin contact; wash thoroughly with soap and water if contact occurs
Eye ProtectionUse safety goggles to prevent contact with eyes; rinse immediately with water if exposed
IngestionNot for ingestion; if swallowed, seek medical advice and avoid inducing vomiting
Disposal MethodsFollow local regulations for disposal of peptides; use biohazard containers for contaminated materials
Emergency ProceduresIn case of accidental exposure, follow standard laboratory emergency protocols and seek medical attention if needed
First Aid MeasuresRinse skin or eyes with plenty of water; remove contaminated clothing; seek medical assistance if symptoms persist
Storage RecommendationsStore in tightly sealed containers at recommended temperatures to maintain stability and prevent degradation
Environmental PrecautionsPrevent release into the environment; dispose of waste properly to minimize environmental impact

FAQs about LL-37 Peptide

Can LL-37 be used to treat infections directly?

LL-37 is a potent antimicrobial peptide with significant efficacy against various pathogens, including bacteria, fungi, and viruses. However, it is currently designated for research use only and is not approved for direct clinical treatment of infections in humans. Researchers are actively studying its potential applications, but its use is restricted to laboratory settings at this time.

How does LL-37 contribute to wound healing?

LL-37 plays a crucial role in wound healing due to its ability to modulate the immune response and promote tissue regeneration. It enhances the recruitment of immune cells to the site of injury, reduces inflammation, and supports the formation of new tissue. Studies have shown that LL-37 can accelerate healing in various wound models, making it a focal point in regenerative medicine research​.

What forms does LL-37 come in for research purposes?

LL-37 is typically available as a lyophilized powder, which can be reconstituted in sterile water or buffers for experimental use. This form ensures the peptide remains stable and effective over time. Researchers use it in various in vitro (test tube) and in vivo (animal) studies to explore its biological functions and therapeutic potential.

How does LL-37 exhibit antiviral properties?

LL-37 has shown promise in inhibiting viral infections, such as those caused by influenza A, respiratory syncytial virus (RSV), and even HIV. It works by disrupting viral membranes and interfering with the replication process of viruses. Although these findings are preliminary and primarily based on cell culture studies, they highlight LL-37’s broad-spectrum antiviral capabilities​.

What are the potential side effects of LL-37 in research settings?

While LL-37 is generally well-tolerated in laboratory studies, potential side effects include local inflammation or immune responses at the site of application. It is essential to follow proper safety protocols when handling LL-37 to minimize any adverse effects. Researchers must carefully monitor any unexpected reactions during experiments involving LL-37​.

Are there any specific guidelines for dosing LL-37 in research?

Dosing guidelines for LL-37 can vary depending on the type of study and the specific goals of the research. Generally, lower doses are used to investigate its antimicrobial and immunomodulatory effects, while higher doses might be explored in studies on wound healing or tissue regeneration. It is crucial to consult detailed protocols and peer-reviewed research to determine the appropriate dosing for specific experiments.

How does LL-37 compare to other antimicrobial peptides?

LL-37 is unique among antimicrobial peptides due to its dual role in both antimicrobial defense and immune modulation. While many antimicrobial peptides primarily disrupt microbial membranes, LL-37 also influences host immune responses, making it a versatile tool in research. Its ability to act against a wide range of pathogens sets it apart from other peptides that may have more narrow targets​.

USER TESTIMONIALS

Our user testimonials reflect genuine experiences and satisfaction. Diverse users have shared their positive outcomes with our Peptides, highlighting its effectiveness and the support they received from our team.

These testimonials provide valuable insights and help new users make informed decisions. Feedback from researchers underscores the peptide’s utility and reliability in various study contexts, reinforcing its value in scientific research.

laveda Strother
laveda Strother
2024-04-14
Has great rc's and peptides.
JT K
JT K
2024-02-24
Friendly
Dustin Schneiter
Dustin Schneiter
2023-12-29
This company is 100% legit. Wish i woukd have found him before the 2 scammers who i came across first. These guys are quick with shipping too
Josh Anthony
Josh Anthony
2023-12-23
Best shop online!!
M B
M B
2023-12-21
This is the first time I've ordered something and then had to report it was contaminated with a Kerosine-like hydrocarbon. No loss of customer. 'Just one o' the last that care 'nuff to say something. Next time will be better, right ?
Robert L
Robert L
2023-10-20
Great company, great products and great customer service!! Thank you for always shipping so quickly!!
Justin Olinger
Justin Olinger
2023-10-12
This is by far my favorite online Peptide vendor that supplies premium Peptides.
Marvin Bedsaul
Marvin Bedsaul
2023-08-15
Very good quality, have only ordered once but plan on ordering again very soon!
Serop Babikian
Serop Babikian
2023-08-09
To be clear I’ve tried every place there is basically. Purerawz literally takes a month if you get anything at all. Biotechpeptides makes the best peptides quality wise, hands down. Peptidessciences is Chinese standard stuff sold like it’s gold. Blue sky peptides is the closest to this, and they fell off years ago. Seriously bluesky is literally the worst quality. Now there’s peptidesforsale. I’ve been w these guys for awhile. Only site I know where if you complain they actually look into it. Peptides are great quality. The chems are legit. The caber worked for me. Letro gave me cracking joints cause I thought it was fake lol. Everything has checked out and they give out amazing g coupons to their loyal customers. This is my go to. I only go to biotech for specific things but everything else these guys.
L Pugh
L Pugh
2023-07-27
Great company with great products. Super fast, discreet, and reliable.

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