S23 SARM 25mg x 30ml
Buy S23 SARM online today at Peptides for Sale. S23 comes in a green 30ml plastic sterile container containing a homogeneous mixture with 25mg per ml of S23 (SARM).
S23 SARM is also known as the following:
S-23, S23, S-23 SARM,
Chemical Structure
S23 SARM Chemical Structure
Chemical Name
(2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide
Chemical Formula
C18H13ClF4N2O3
Molar mass
416.753 g/mol
Description
S23’s pharmacologic effects were characterized in male rats as a hormonal male contraception. S-23 showed high binding affinity (inhibitory constant = 1.7 +/- 0.2 nm) and was identified as a full agonist in vitro.
In castrated male rats, the ED50 of S-23 in the prostate and levator ani muscle was 0.43 and 0.079 mg/d, respectively whereas in intact male rats treated for 14 d, S-23 alone suppressed LH levels by greater than 50% at doses greater than 0.1 mg/d, with corresponding decreases in the size of the prostate but increases in the size of levator ani muscle.
In intact male rats treated for up to 10 wk with S-23 and estradiol benzoate (EB; necessary to maintain sexual behavior in rats), S-23 showed biphasic effects on androgenic tissues and spermatogenesis by suppressing serum concentrations of LH and FSH. EB alone showed no effect on spermatogenesis. In the EB + S-23 (0.1 mg/d) group, four of six animals showed no sperm in the testis and zero pregnancies (none of six) in mating trials.
Infertility was fully reversible after termination of treatment and had a 100% pregnancy rate observed after a 100-day recovery. S-23 increased bone mineral density and lean mass but reduced fat mass in a dose-dependent manner. This first study shows a selective androgen receptor modulator combined with EB is an effective and reversible regimen for hormonal male contraception in rats. The beneficial effects of S-23 on the muscle, tissue selectivity, and favorable pharmacokinetic properties make it a strong candidate for use in oral male contraception.
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